Item Details

title

A potential biologic role for the meniscus in the development of osteoarthritis.

author

Stone, Austin V.

abstract

The overarching goal of this research is to identify the biologic role of the meniscus in the development of osteoarthritis. We hypothesized that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which could contribute to joint tissue destruction and subsequent development of osteoarthritis. We examined meniscus pathology in established osteoarthritis, characterized the alterations in meniscus cell processes between normal and osteoarthritic menisci, and explored potential pathways involved in osteoarthritis pathogenesis including a novel pathway proposed to mediate osteoarthritis development.

subject

cartilage

chemokine

cytokine

meniscus

MMP

osteoarthritis

contributor

Ferguson, Cristin M (committee chair)

Loeser, Richard F (committee member)

Yammani, Raghunatha R (committee member)

Callahan, Michael F (committee member)

Van Dyke, Mark E (committee member)

date

2013-08-23T08:35:19Z (accessioned)

2014-02-23T09:30:12Z (available)

2013 (issued)

degree

Molecular Medicine and Translational Science (discipline)

embargo

2014-2-23 (terms)

identifier

http://hdl.handle.net/10339/39030 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation