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A potential biologic role for the meniscus in the development of osteoarthritis.

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abstract
The overarching goal of this research is to identify the biologic role of the meniscus in the development of osteoarthritis. We hypothesized that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which could contribute to joint tissue destruction and subsequent development of osteoarthritis. We examined meniscus pathology in established osteoarthritis, characterized the alterations in meniscus cell processes between normal and osteoarthritic menisci, and explored potential pathways involved in osteoarthritis pathogenesis including a novel pathway proposed to mediate osteoarthritis development.
subject
cartilage
chemokine
cytokine
meniscus
MMP
osteoarthritis
contributor
Stone, Austin V. (author)
Ferguson, Cristin M (committee chair)
Loeser, Richard F (committee member)
Yammani, Raghunatha R (committee member)
Callahan, Michael F (committee member)
Van Dyke, Mark E (committee member)
date
2013-08-23T08:35:19Z (accessioned)
2014-02-23T09:30:12Z (available)
2013 (issued)
degree
Molecular Medicine and Translational Science (discipline)
embargo
2014-2-23 (terms)
identifier
http://hdl.handle.net/10339/39030 (uri)
language
en (iso)
publisher
Wake Forest University
title
A potential biologic role for the meniscus in the development of osteoarthritis.
type
Dissertation

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