Item Details

title

Improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment

author

Scarpinato, Karin Drotschmann

author

AbdelHafez, ElShimaa

author

Diamanduros, Andrew

author

Negureanu, Lacramioara

author

Lu, Yan

author

Bean, Jessica Hayley

author

Zielke, Katherine

author

Crowe, Brittany

author

Vasilyeva, Aksana

author

Clodfelter, Jill

author

Aly, Omar

author

Abuo-Rahma, Gamal

author

Salsbury, Freddie R.

author

King, Stephen Bruce

abstract

We, and others have previously shown that mismatch repair proteins, in addition to their repair function, have the ability to contribute to cell death initiation. In response to some drugs, this cell death activity is independent of the repair function of the proteins. Rescinnamine, a derivative of the indole alkaloid reserpine, a drug used to treat hypertension several decades ago, was shown to target the cell death-initiating activity of mismatch repair proteins. When used in animals, the hypotensive action of this drug prevents applying appropriate concentrations for statistically significant tumor reduction. Here we used a combination of computational modeling, chemical synthesis and cell assays to determine how rescinnamine can be modified and what effect these modifications have on cell survival. Results inform further computational modeling to suggest new lead molecules to move toward further testing.

subject

mismatch repair

apoptosis

rescinnamine

citation

1 (issue)

1 (volume)

date

2013-11-05T19:04:56Z (accessioned)

2013-11-05T19:04:56Z (available)

2013 (issued)

identifier

Scarpinato, K.D., et al. (2013). Improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment." Molecular Cancer Biology, 1(1): 27pp. Available at http://eopenaccess.com/index.php/mcb/article/view/42. (citation)

2168-0922 (issn)

http://hdl.handle.net/10339/39070 (uri)

http://eopenaccess.com/index.php/mcb/article/view/42 (uri)

publisher

eOpen Access Publishing

source

Molecular Cancer Biology

type

Article