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Behavioral Models of Cocaine Use Disorder

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abstract
The complex set of symptoms associated with substance use disorder has made creating animal models with high predictive validity difficult. One tactic to help translate results from animal studies to humans is to separate the symptoms of substance use disorder into two broad categories of dysregulated drug taking and dysregulated drug seeking. However, distinguishing the drug seeking or drug taking components in self-administration models can be difficult since the consumptive and appetitive responses are both directed towards the same operant. A variety of analysis methods, procedures, and schedules of reinforcement can be used to help separate the conflated consumptive vs appetitive aspects of self-administration, and distinguishing these characteristics represents a unique lens with which to examine results from self-administration studies.
subject
appetitive
cocaine
consumptive
drug-seeking
drug-taking
self-administration
contributor
Zimmer, Benjamin A. (author)
Roberts, David CS (committee chair)
Stanford, Terrance R (committee member)
Jones, Sara R (committee member)
McCool, Brian A (committee member)
Weiner, Jeffrey L (committee member)
date
2014-01-15T09:35:18Z (accessioned)
2014-01-15T09:35:18Z (available)
2013 (issued)
degree
Neuroscience (discipline)
identifier
http://hdl.handle.net/10339/39109 (uri)
language
en (iso)
publisher
Wake Forest University
title
Behavioral Models of Cocaine Use Disorder
type
Dissertation

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