Item Details

abstract

The complex set of symptoms associated with substance use disorder has made creating animal models with high predictive validity difficult. One tactic to help translate results from animal studies to humans is to separate the symptoms of substance use disorder into two broad categories of dysregulated drug taking and dysregulated drug seeking. However, distinguishing the drug seeking or drug taking components in self-administration models can be difficult since the consumptive and appetitive responses are both directed towards the same operant. A variety of analysis methods, procedures, and schedules of reinforcement can be used to help separate the conflated consumptive vs appetitive aspects of self-administration, and distinguishing these characteristics represents a unique lens with which to examine results from self-administration studies.

subject

appetitive

cocaine

consumptive

drug-seeking

drug-taking

self-administration

contributor

Zimmer, Benjamin A. (author)

Roberts, David CS (committee chair)

Stanford, Terrance R (committee member)

Jones, Sara R (committee member)

McCool, Brian A (committee member)

Weiner, Jeffrey L (committee member)

date

2014-01-15T09:35:18Z (accessioned)

2014-01-15T09:35:18Z (available)

2013 (issued)

degree

Neuroscience (discipline)

identifier

http://hdl.handle.net/10339/39109 (uri)

language

en (iso)

publisher

Wake Forest University

title

Behavioral Models of Cocaine Use Disorder

type

Dissertation