RADIATION-INDUCED BRAIN INJURY: NOT JUST A MICROGLIA AND HIPPOCAMPUS STORY ANYMORE
Electronic Theses and Dissertations
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- abstract
- As the population of long-term cancer survivors increases, quality of life (QOL) is becoming an important aspect of cancer therapy. The majority of brain tumor patients surviving 6 months after fractionated whole brain irradiation (fWBI) will develop progressive, irreversible cognitive impairment that has a significant effect on their QOL. Although the mechanism(s) behind the development of radiation-induced brain injury, including cognitive impairment, are unknown, hippocampal microglia-mediated neuroinflammation and altered neuronal function are hypothesized to play a role. However, cognitive studies with renin-angiotensin system (RAS) blockers which increase Ang-(1-7), indicate that microglia and the hippocampus may not be the complete story. Thus, we hypothesized that radiation-induced brain injury may be prevented by i] targeting neuroinflammation in brain cells other than microglia, and by ii] altering neuronal function in other brain regions (e.g. cortex).
- subject
- Angiotensin-(1-7)
- Brain
- Cognition
- Homer1a
- Radiation
- contributor
- Metheny-Barlow, Linda J (committee chair)
- Gallagher, Patricia (committee member)
- Blackstock, William (committee member)
- Miller, Lance (committee member)
- Seals, Darren (committee member)
- Riddle, David (committee member)
- date
- 2014-01-15T09:35:35Z (accessioned)
- 2015-01-15T09:30:08Z (available)
- 2013 (issued)
- degree
- Cancer Biology (discipline)
- embargo
- 2015-01-15 (terms)
- identifier
- http://hdl.handle.net/10339/39139 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- RADIATION-INDUCED BRAIN INJURY: NOT JUST A MICROGLIA AND HIPPOCAMPUS STORY ANYMORE
- type
- Dissertation