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Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer

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abstract
Breast cancer is the second most common cause of cancer related death in women. Decades of research have demonstrated complexity and high heterogeneity of this disease. The tumor heterogeneity is a result of many altered genomic, epigenomic, and protein modification states that contribute to a distinctive proliferative advantage. The same deregulations that initiate tumorigenesis of mammary epithelial cells are believed to coerce therapeutic resistance. On the other hand, population-wide screenings have increased diagnosis of women with breast cancers without specificity for the tumors with an aggressive phenotype. Hence, identification of the cancer cell's intrinsic alterations that faithfully predict tumor progression has a potential to significantly improve their clinical management.
subject
ARF
Breast Cancer
DMP1
HER2
p53
Tumor suppressor
contributor
Maglic, Dejan (author)
Sui, Guangchao (committee chair)
Loeser, Richard F (committee member)
Kulik, George (committee member)
Miller, Lance D (committee member)
Pardee, Timothy S (committee member)
date
2014-07-10T08:35:20Z (accessioned)
2015-07-10T08:30:09Z (available)
2014 (issued)
degree
Cancer Biology (discipline)
embargo
2015-07-10 (terms)
identifier
http://hdl.handle.net/10339/39244 (uri)
language
en (iso)
publisher
Wake Forest University
title
Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer
type
Dissertation

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