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SOX7 is downregulated and functions as a tumor suppressive transcription factor in breast cancer

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abstract
Second only to lung cancer, breast cancer is the leading cause of cancer-related deaths in American women. Breast cancer is a heterogeneous set of diseases characterized by aberrant genetic and epigenetic states, often leading to the ablation of tumor suppressors. Loss of tumor suppressor function has been established as a driver of disease progression in breast cancer patients. Thus, understanding the deregulation of tumor suppressor activity may lead to the identification of potential therapeutic targets whose inhibition can restore tumor suppressor function and, consequently, an anti-proliferative cellular state.
subject
breast cancer
epigenetics
noncoding RNA
SOX7
tumor suppressor
contributor
Stovall, Daniel B. (author)
Sui, Guangchao (committee chair)
Wang, Yuh-Hwa (committee member)
Seals, Darren F (committee member)
Pardee, Timothy S (committee member)
Wadas, Thaddeus (committee member)
date
2014-07-10T08:35:34Z (accessioned)
2014-07-10T08:35:34Z (available)
2014 (issued)
degree
Cancer Biology (discipline)
identifier
http://hdl.handle.net/10339/39287 (uri)
language
en (iso)
publisher
Wake Forest University
title
SOX7 is downregulated and functions as a tumor suppressive transcription factor in breast cancer
type
Dissertation

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