Item Details

title

SOX7 is downregulated and functions as a tumor suppressive transcription factor in breast cancer

author

Stovall, Daniel B.

abstract

Second only to lung cancer, breast cancer is the leading cause of cancer-related deaths in American women. Breast cancer is a heterogeneous set of diseases characterized by aberrant genetic and epigenetic states, often leading to the ablation of tumor suppressors. Loss of tumor suppressor function has been established as a driver of disease progression in breast cancer patients. Thus, understanding the deregulation of tumor suppressor activity may lead to the identification of potential therapeutic targets whose inhibition can restore tumor suppressor function and, consequently, an anti-proliferative cellular state.

subject

breast cancer

epigenetics

noncoding RNA

SOX7

tumor suppressor

contributor

Sui, Guangchao (committee chair)

Wang, Yuh-Hwa (committee member)

Seals, Darren F (committee member)

Pardee, Timothy S (committee member)

Wadas, Thaddeus (committee member)

date

2014-07-10T08:35:34Z (accessioned)

2014-07-10T08:35:34Z (available)

2014 (issued)

degree

Cancer Biology (discipline)

identifier

http://hdl.handle.net/10339/39287 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation