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A Keratin Biomaterial for Treatment Following Spinal Cord Hemisection Injury and Investigation of Secondary Damage Mechanisms

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abstract
Spinal cord injuries (SCI) are a severely debilitating injury that affects about 200,000 people in the United States alone. The only current treatment options include use of steroids, spinal fixation surgery, and rehabilitation, none of which provide any significant recovery of function. SCIs are particularly difficult to treat because of the inhibitory nature of the lesion site and overcoming it to allow for repair and regeneration. There are many contributing factors to secondary damage, including the inflammatory response that follows SCI. Peripheral immune cells are able to infiltrate to the site of injury through the damaged blood-spinal cord barrier (BSB). It is well-established that macrophages play a major role in this process and, in response to SCI, are known to polarize to a proinflammatory phenotype that promotes secondary degeneration. These M1 macrophages dominate at the lesion site with concurrent downregulation of the M2 anti-inflammatory, growth supporting phenotype.
subject
biomaterial
inflammation
macrophage
spinal cord injury
contributor
Fearing, Bailey (author)
Van Dyke, Mark E (committee chair)
Tytell, Mike (committee member)
Milligan, Carol (committee member)
High, Kevin (committee member)
Howland, Dena (committee member)
date
2014-07-10T08:35:36Z (accessioned)
2015-07-10T08:30:09Z (available)
2014 (issued)
degree
Molecular Medicine and Translational Science (discipline)
embargo
2015-07-10 (terms)
identifier
http://hdl.handle.net/10339/39298 (uri)
language
en (iso)
publisher
Wake Forest University
title
A Keratin Biomaterial for Treatment Following Spinal Cord Hemisection Injury and Investigation of Secondary Damage Mechanisms
type
Dissertation

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