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Molecular Mechanisms for the Angiotensin-(1-7)-Mediated Inhibition of Metastatic Triple Negative Breast Cancer

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abstract
Approximately 40,000 women in the U.S. die from breast cancer annually. An estimated 15% of all breast cancers are triple negative, wherein tumors lack estrogen receptor and progesterone receptor expression and possess unamplified human epidermal growth factor receptor 2 (HER2) levels, contributing to an absence of effective, targeted therapeutics. Furthermore, triple negative breast cancer (TNBC) is highly-aggressive with greater patient mortality rates compared with other breast cancer subtypes, necessitating development of novel treatment options.
subject
contributor
Arter, Alison (author)
Tallant, Ann (committee chair)
Metheny-Barlow, Linda (committee member)
Miller, Mark S (committee member)
Levi-Polyachenko, Nicole H (committee member)
date
2014-07-10T08:35:38Z (accessioned)
2015-07-10T08:30:09Z (available)
2014 (issued)
degree
Physiology and Pharmacology (discipline)
embargo
2015-07-10 (terms)
identifier
http://hdl.handle.net/10339/39307 (uri)
language
en (iso)
publisher
Wake Forest University
title
Molecular Mechanisms for the Angiotensin-(1-7)-Mediated Inhibition of Metastatic Triple Negative Breast Cancer
type
Dissertation

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