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Ethosuximide, a T-type Calcium Channel Antagonist, Reduces Alcohol Withdrawal Seizure

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abstract
Alcohol is the third highest risk factor for health related problems in the world and leads to over two million deaths per year. Individuals abusing alcohol frequently cycle between drinking and withdrawal states, which among other adverse side effects can induce withdrawal seizures. Alcohol withdrawal seizures are a major component of relapse and represent a significant barrier to recovery. Unfortunately, alcohol withdrawal seizures can cause more serious consequences such as status epilepticus and temporal lobe epilepsy, severe life-threatening conditions that often result in death.
subject
alcohol
ethosuximide
seizure
T-type calcium channel
withdrawal
contributor
Riegle, Melissa Ann (author)
Godwin, Dwayne W (committee chair)
Salinas, Emilio (committee member)
Jones, Sara (committee member)
McCool, Brian (committee member)
Weiner, Jeff (committee member)
date
2014-07-10T08:35:43Z (accessioned)
2015-07-10T08:30:11Z (available)
2014 (issued)
degree
Neuroscience (discipline)
embargo
2015-07-10 (terms)
identifier
http://hdl.handle.net/10339/39329 (uri)
language
en (iso)
publisher
Wake Forest University
title
Ethosuximide, a T-type Calcium Channel Antagonist, Reduces Alcohol Withdrawal Seizure
type
Dissertation

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