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Blood Pressure Regulation by the Endocannabinoid System in Conditions Associated with Hypertension

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abstract
Hypertension is associated with various conditions including obesity, type II diabetes and aging. Despite decades of research, the mechanisms involved in the development of hypertension are still poorly understood. Emerging evidence suggests hypertension is mediated by an imbalance in autonomic nervous system activity. Baroreflex sensitivity for control of heart rate, an important index of vagus nerve function as well as general morbidity and mortality, is often impaired in conditions associated with hypertension. Restoration of baroreflex function is now recognized as a therapeutic strategy for prevention of cardiovascular diseases. Therefore, it is crucial to identify key factors that regulate brainstem regions controlling autonomic outflow in conditions associated with baroreflex dysfunction.
subject
Autonomic Nervous System
Baroreflex
Endocannabinoid System
Hypertension
Renin-Angiotensin System
contributor
Schaich, Chris (author)
Diz, Debra I (committee chair)
Howlett, Allyn C (committee member)
Pratt, Wayne E (committee member)
Shaltout, Hossam A (committee member)
Thomas, Brian F (committee member)
date
2014-07-10T08:35:43Z (accessioned)
2014-07-10T08:35:43Z (available)
2014 (issued)
degree
Physiology and Pharmacology (discipline)
identifier
http://hdl.handle.net/10339/39330 (uri)
language
en (iso)
publisher
Wake Forest University
title
Blood Pressure Regulation by the Endocannabinoid System in Conditions Associated with Hypertension
type
Dissertation

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