Item Details

title

Blood Pressure Regulation by the Endocannabinoid System in Conditions Associated with Hypertension

author

Schaich, Chris

abstract

Hypertension is associated with various conditions including obesity, type II diabetes and aging. Despite decades of research, the mechanisms involved in the development of hypertension are still poorly understood. Emerging evidence suggests hypertension is mediated by an imbalance in autonomic nervous system activity. Baroreflex sensitivity for control of heart rate, an important index of vagus nerve function as well as general morbidity and mortality, is often impaired in conditions associated with hypertension. Restoration of baroreflex function is now recognized as a therapeutic strategy for prevention of cardiovascular diseases. Therefore, it is crucial to identify key factors that regulate brainstem regions controlling autonomic outflow in conditions associated with baroreflex dysfunction.

subject

Autonomic Nervous System

Baroreflex

Endocannabinoid System

Hypertension

Renin-Angiotensin System

contributor

Diz, Debra I (committee chair)

Howlett, Allyn C (committee member)

Pratt, Wayne E (committee member)

Shaltout, Hossam A (committee member)

Thomas, Brian F (committee member)

date

2014-07-10T08:35:43Z (accessioned)

2014-07-10T08:35:43Z (available)

2014 (issued)

degree

Physiology and Pharmacology (discipline)

identifier

http://hdl.handle.net/10339/39330 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation