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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION

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abstract
Cannabis, or marijuana, is the most commonly used illicit drug in the United States. The CB1 cannabinoid receptor (CB1R) has been extensively studied since the initial characterization of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in the CNS and has been targeted therapeutically for multiple diseases; however side effect profiles for CB1R have posed difficulty in the development of clinically successful CB1R drugs. The identification of GPCR interacting proteins has provided additional insight into the fine-tuning and regulation of numerous GPCR's. The Cannabinoid Receptor Interacting Protein 1a (CRIP1a) binds to the extreme carboxy terminus of CB1R, and has been shown to alter CB1R-mediated neuronal function. The mechanisms by which CRIP1a regulates CB1R activity and trafficking have not yet been identified; therefore the focus of this dissertation is to examine the cellular effects of CRIP1a on CB1R function and cellular trafficking.
subject
B-ARRESTIN
CB1R
CRIP1A
GPCR
SIGNALING
contributor
Blume, Lawrence Christopher (author)
Howlett, Allyn C (committee chair)
Lowther, Todd (committee member)
Childers, Steven R. (committee member)
Chen, Rong (committee member)
Selley, Dana E. (committee member)
date
2014-07-10T08:35:44Z (accessioned)
2015-07-10T08:30:11Z (available)
2014 (issued)
degree
Physiology and Pharmacology (discipline)
embargo
2015-07-10 (terms)
identifier
http://hdl.handle.net/10339/39334 (uri)
language
en (iso)
publisher
Wake Forest University
title
CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
type
Dissertation

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