Item Details

abstract

Cannabis, or marijuana, is the most commonly used illicit drug in the United States. The CB1 cannabinoid receptor (CB1R) has been extensively studied since the initial characterization of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in the CNS and has been targeted therapeutically for multiple diseases; however side effect profiles for CB1R have posed difficulty in the development of clinically successful CB1R drugs. The identification of GPCR interacting proteins has provided additional insight into the fine-tuning and regulation of numerous GPCR's. The Cannabinoid Receptor Interacting Protein 1a (CRIP1a) binds to the extreme carboxy terminus of CB1R, and has been shown to alter CB1R-mediated neuronal function. The mechanisms by which CRIP1a regulates CB1R activity and trafficking have not yet been identified; therefore the focus of this dissertation is to examine the cellular effects of CRIP1a on CB1R function and cellular trafficking.

subject

B-ARRESTIN

CB1R

CRIP1A

GPCR

SIGNALING

contributor

Blume, Lawrence Christopher (author)

Howlett, Allyn C (committee chair)

Lowther, Todd (committee member)

Childers, Steven R. (committee member)

Chen, Rong (committee member)

Selley, Dana E. (committee member)

date

2014-07-10T08:35:44Z (accessioned)

2015-07-10T08:30:11Z (available)

2014 (issued)

degree

Physiology and Pharmacology (discipline)

embargo

2015-07-10 (terms)

identifier

http://hdl.handle.net/10339/39334 (uri)

language

en (iso)

publisher

Wake Forest University

title

CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION

type

Dissertation