Item Details

abstract

In this thesis, we will evaluate the effect of anthracycline chemotherapy on measures of myocardial injury and fibrosis using quantitative cardiovascular magnetic resonance (CMR) imaging techniques. Anthracycline-based chemotherapy regimens are often an essential component of curative cancer treatments, but are associated with myocardial injury, heart failure, and cardiovascular events. Elevated native T1 and extracellular volume (ECV) assessments indicative of myocardial fibrosis or injury have been observed in adult cancer survivors treated with anthracyclines. It remains undetermined, however, whether these measures are related to the cancer or the treatment for cancer.

subject

Cardiotoxicity

Cardiovascular Magnetic Resonance Imaging

Extracellular Volume

Myocardial Fibrosis

Myocardial T1

contributor

Jordan, Jennifer Hawthorne (author)

Hundley, William G (committee chair)

Burke, Gregory L (committee member)

Hamilton, Craig A (committee member)

Morgan, Timothy M (committee member)

date

2015-01-21T09:35:18Z (accessioned)

2014 (issued)

degree

Clinical and Population Translational Sciences (discipline)

10000-01-01 (liftdate)

embargo

forever (terms)

identifier

http://hdl.handle.net/10339/47458 (uri)

language

en (iso)

publisher

Wake Forest University

title

Assessment of Myocardial Fibrosis using Cardiovascular Magnetic Resonance Extracellular Volume Mapping in Cancer Patients Treated with Anthracycline-based Chemotherapy Compared with Untreated Cancer Patients and Cancer-free Peers

type

Thesis