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Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models

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abstract
Prostate cancer (CaP) is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths in American men. Despite earlier detection, CaP continues to be fatal in ~10% of cases and better treatments for patients with advanced disease are desperately needed. Understanding the molecular pathways involved in CaP initiation, progression, and resistance to treatment may help identify novel therapeutic targets. However, the molecular complexity of individual CaP genomes along with the heterogeneity observed between patients suggests that multiple molecular subtypes of CaP exist.
subject
CHD1
MAP3K7
prostate cancer
stem cell
tissue recombination
tumor suppressor
contributor
Rodrigues, Lindsey Ulkus (author)
Cramer, Scott D (committee chair)
Alexander-Miller, Martha A (committee member)
Kridel, Steven J (committee member)
Liu, Wennuan (committee member)
Lyles, Douglas S (committee member)
date
2015-01-21T09:35:19Z (accessioned)
2017-01-21T09:30:13Z (available)
2014 (issued)
degree
Cancer Biology (discipline)
embargo
2017-01-21 (terms)
identifier
http://hdl.handle.net/10339/47459 (uri)
language
en (iso)
publisher
Wake Forest University
title
Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models
type
Dissertation

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