Item Details

title

Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models

author

Rodrigues, Lindsey Ulkus

abstract

Prostate cancer (CaP) is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths in American men. Despite earlier detection, CaP continues to be fatal in ~10% of cases and better treatments for patients with advanced disease are desperately needed. Understanding the molecular pathways involved in CaP initiation, progression, and resistance to treatment may help identify novel therapeutic targets. However, the molecular complexity of individual CaP genomes along with the heterogeneity observed between patients suggests that multiple molecular subtypes of CaP exist.

subject

CHD1

MAP3K7

prostate cancer

stem cell

tissue recombination

tumor suppressor

contributor

Cramer, Scott D (committee chair)

Alexander-Miller, Martha A (committee member)

Kridel, Steven J (committee member)

Liu, Wennuan (committee member)

Lyles, Douglas S (committee member)

date

2015-01-21T09:35:19Z (accessioned)

2017-01-21T09:30:13Z (available)

2014 (issued)

degree

Cancer Biology (discipline)

embargo

2017-01-21 (terms)

identifier

http://hdl.handle.net/10339/47459 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation