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Variability of Neural Responses in the Lateral Prefrontal Cortex

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title
Variability of Neural Responses in the Lateral Prefrontal Cortex
author
King, Samson Garret
abstract
The neurophysiological signature of visuospatial working memory is a conspicuous persistent activity throughout a delay period in which the stimulus is absent. The dorsolateral prefrontal cortex has long been implicated as the seat of visuospatial working memory, and undergoes dramatic increases in volume and functional connectivity during and around the time of puberty. However, much of the neurophysiological changes between the two developmental periods remains obscured, including that of how response variability changes. This is important, since recent studies have shown that mean firing rate alone may not be sufficient to fully explain neural responses as a function of task demands and stimulus intensity. Here, we address two primary questions: First, does response variability change significantly as a function of pubertal development? And second, does task difficulty modulate response variability in any meaningful way? We also looked at possible effects of the hemifield of the response on variability. What we found was a modest effect of development on Fano factor during the cue epoch and a generally higher Fano factor for ipsilateral responses in adult monkeys. Task difficulty had no definitive effects on response variability as measured by the Fano factor here.
subject
development
Fano factor
macaque
prefrontal cortex
task difficulty
variability
contributor
Constantinidis, Christos (committee chair)
Rowland, Benjamin A (committee member)
Hampson, Robert E (committee member)
Stanford, Terrence R (committee member)
date
2015-06-23T08:35:32Z (accessioned)
2017-06-22T08:30:10Z (available)
2015 (issued)
degree
Neurobiology & Anatomy (discipline)
embargo
2017-06-22 (terms)
identifier
http://hdl.handle.net/10339/57095 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

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