Item Details

abstract

There are currently no FDA-approved drug treatments for cocaine abuse. The use of female subjects and a better understanding of the influence of hormones and cognitive function may provide valuable information to aid in pharmacotherapy development. The present studies utilized female monkeys housed in groups of four to examine the interactions of social rank and hormone concentrations on vulnerability to cocaine reinforcement and cognitive function. The overarching goal was to characterize how estradiol (E2) and progesterone (P4) concentrations influence cognitive performance, eventual social rank and vulnerability to cocaine self-administration (SA). We also examined how social rank altered these and additional hormonal measures.

subject

cocaine

cognition

estradiol

monkey

social rank

contributor

Kromrey, Sarah Allyson (author)

Nader, Michael (committee chair)

Voytko, MaryLou (committee member)

Appt, Susan (committee member)

Kaplan, Jay (committee member)

date

2015-06-23T08:35:36Z (accessioned)

2017-06-22T08:30:10Z (available)

2015 (issued)

degree

Neuroscience (discipline)

embargo

2017-06-22 (terms)

identifier

http://hdl.handle.net/10339/57103 (uri)

language

en (iso)

publisher

Wake Forest University

title

Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration

type

Dissertation