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Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration

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abstract
There are currently no FDA-approved drug treatments for cocaine abuse. The use of female subjects and a better understanding of the influence of hormones and cognitive function may provide valuable information to aid in pharmacotherapy development. The present studies utilized female monkeys housed in groups of four to examine the interactions of social rank and hormone concentrations on vulnerability to cocaine reinforcement and cognitive function. The overarching goal was to characterize how estradiol (E2) and progesterone (P4) concentrations influence cognitive performance, eventual social rank and vulnerability to cocaine self-administration (SA). We also examined how social rank altered these and additional hormonal measures.
subject
cocaine
cognition
estradiol
monkey
social rank
contributor
Kromrey, Sarah Allyson (author)
Nader, Michael (committee chair)
Voytko, MaryLou (committee member)
Appt, Susan (committee member)
Kaplan, Jay (committee member)
date
2015-06-23T08:35:36Z (accessioned)
2017-06-22T08:30:10Z (available)
2015 (issued)
degree
Neuroscience (discipline)
embargo
2017-06-22 (terms)
identifier
http://hdl.handle.net/10339/57103 (uri)
language
en (iso)
publisher
Wake Forest University
title
Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration
type
Dissertation

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