CHARACTERIZING THE MICRO-SCALE MECHANICAL PROPERTIES OF HYDROGELS AND CANCER CELLS
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- title
- CHARACTERIZING THE MICRO-SCALE MECHANICAL PROPERTIES OF HYDROGELS AND CANCER CELLS
- author
- Guo, Xinyi
- abstract
- Tissue engineering strategies nowadays require attention to not only cells, but also to the mechanical properties of the extracellular matrix (ECM).We studied the elasticity of hydrogels formulations frequently used in cell and tissue culturing. A variety of concentrations in a variety of biomaterials, including agarose, alginate, the collagens, fibrin, hyaluronic acid, kerateine, laminin, Matrigel, and polyethylene glycol diacrylate (PEGDA), were tested with atomic force microscopy (AFM). We also determined the Young’s modulus (E) of hydrogels with different concentrations. E tended to increase with increased concentration.
- subject
- Atomic Force Microscopy
- Breast Cancer
- Cancer cells
- Hydrogels
- Multiple Myeloma
- Young's Modulus
- contributor
- Guthold, Martin (committee chair)
- Bierbach, Ulrich (committee member)
- Holzwarth, George (committee member)
- Macosko, Jed (committee member)
- Guthold, Martin (committee member)
- date
- 2015-06-23T08:35:43Z (accessioned)
- 2015-06-23T08:35:43Z (available)
- 2015 (issued)
- degree
- Physics (discipline)
- identifier
- http://hdl.handle.net/10339/57120 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- type
- Dissertation