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CHARACTERIZING THE MICRO-SCALE MECHANICAL PROPERTIES OF HYDROGELS AND CANCER CELLS

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title
CHARACTERIZING THE MICRO-SCALE MECHANICAL PROPERTIES OF HYDROGELS AND CANCER CELLS
author
Guo, Xinyi
abstract
Tissue engineering strategies nowadays require attention to not only cells, but also to the mechanical properties of the extracellular matrix (ECM).We studied the elasticity of hydrogels formulations frequently used in cell and tissue culturing. A variety of concentrations in a variety of biomaterials, including agarose, alginate, the collagens, fibrin, hyaluronic acid, kerateine, laminin, Matrigel, and polyethylene glycol diacrylate (PEGDA), were tested with atomic force microscopy (AFM). We also determined the Young’s modulus (E) of hydrogels with different concentrations. E tended to increase with increased concentration.
subject
Atomic Force Microscopy
Breast Cancer
Cancer cells
Hydrogels
Multiple Myeloma
Young's Modulus
contributor
Guthold, Martin (committee chair)
Bierbach, Ulrich (committee member)
Holzwarth, George (committee member)
Macosko, Jed (committee member)
Guthold, Martin (committee member)
date
2015-06-23T08:35:43Z (accessioned)
2015-06-23T08:35:43Z (available)
2015 (issued)
degree
Physics (discipline)
identifier
http://hdl.handle.net/10339/57120 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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