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Biosynthetic and Functional Studies of Bacillithiol in Gram-positive Bacteria

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title
Biosynthetic and Functional Studies of Bacillithiol in Gram-positive Bacteria
author
Fang, Zhong
abstract
Low-molecular-weight (LMW) thiols play vital roles on a variety of cell metabolic pathways including oxidative stress management, xenobiotic detoxification, post-translational modification, and metal homeostasis. Previous studies have identified glutathione (GSH) as the dominant LMW thiol in eukaryotic cells as well as Gram-negative bacteria and mycothiol (MSH) as the dominant LMW thiol in Actinobacteria. Functional studies on those thiols have revealed their importance in cell metabolism, also their potential as target for antimicrobial development. Interestingly, neither GSH nor MSH was found in low G+C Gram-positive bacteria, including some notable pathogens, such as B. anthracis, B. cereus and S. aureus, etc. In 2009, a novel LMW thiol, bacillithiol (BSH), was identified in this class of bacteria and suggested to play analogous function as GSH and MSH.
subject
Bacillithiol
deacetylase
Fe-S cluster
Nfu
NifS
contributor
Dos Santos, Patricia C. (committee chair)
Claiborne, Henry A (committee member)
Alexander, Rebecca W (committee member)
King, Stephen B (committee member)
Welker, Mark E (committee member)
date
2015-06-23T08:35:45Z (accessioned)
2015-12-22T09:30:08Z (available)
2015 (issued)
degree
Chemistry (discipline)
embargo
2015-12-22 (terms)
identifier
http://hdl.handle.net/10339/57126 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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