Item Details

abstract

Heart Failure with preserved Ejection fraction (HFpEF) is a cardiovascular condition which is steadily on the rise. It is a major affliction in the elderly with higher incident rates in females and the obese. Exercise intolerance even to submaximal exercise is the cardinal symptom of this disease. Clinical trials have shown an improvement in the quality of life and stamina in patients after supervised exercise training. Recent studies have indicated determinants to exercise intolerance may be present in peripheral micro-vasculature & skeletal muscle function, in addition to cardiovascular deficiencies. Traditionally, HFpEF studies have been conducted via ultrasonography in the past. The thesis is proposing a Magnetic resonance imaging (MR) protocol which can efficiently map peripheral blood flow, skeletal fat composition and exercise ability of subjects during the exercise training visits. Detailed temporal information gathered from visits and longitudinal data over the duration of study can help us understand reasons of the exercise intolerance better.

subject

Dixon's Technique

HFpEF

MRI

pCASL

contributor

Mishra, Sourav (author)

Kraft, Robert A (committee chair)

Hamilton, Craig A (committee member)

Kitzman, Dalane W (committee member)

date

2015-06-23T08:35:50Z (accessioned)

2017-06-22T08:30:10Z (available)

2015 (issued)

degree

Biomedical Engineering (discipline)

embargo

2017-06-22 (terms)

identifier

http://hdl.handle.net/10339/57137 (uri)

language

en (iso)

publisher

Wake Forest University

title

Investigation and analysis of heart failure with preserved ejection fraction (HFpEF) with Magnetic resonance

type

Thesis