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Development of the African Green Monkey as a Model for Complement-Mediated Neutralization of Myxoviruses

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title
Development of the African Green Monkey as a Model for Complement-Mediated Neutralization of Myxoviruses
author
Mayer, Anne E.
abstract
Complement (C') plays a significant role in the innate immune response to myxoviruses such as parainfluenza viruses (PIV) and influenza A virus (IAV). The regulation of C' activity to balance control of virus spread while preventing a hyperinflammatory environment can have important implications for human health. The overall goal of our work was to develop the African green monkey (AGM) as a model to dissect the role of C' in neutralization of myxoviruses. First, we determined the contribution of C' to the neutralizing capacity of antibodies (Abs) elicited by respiratory tract infection of AGMs with PIV. Then we shifted to assessing changes in C' response to IAV infection during pregnancy--a physiologic environment that requires alterations in C' to maintain a healthy inflammatory environment for the mother and developing fetus.
subject
Complement
Influenza virus
Innate Immunity
Nonhuman Primates
Parainfluenza Virus
Pregnancy
contributor
Parks, Griffith D (committee chair)
Ornelles, David A (committee member)
Alexander-Miller, Martha A (committee member)
Haas, Karen L (committee member)
Kavanagh, Kylie (committee member)
date
2015-06-23T08:35:58Z (accessioned)
2015-06-23T08:35:58Z (available)
2015 (issued)
degree
Microbiology & Immunology (discipline)
identifier
http://hdl.handle.net/10339/57172 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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