Item Details

abstract

Hydrogen peroxide (H2O2) and its metabolites participate in cellular redox homeostasis and have become well documented in recent years as messengers in signal transduction. One important mechanism by which redox-based signaling happens is reversible oxidation of cysteine residues forming cysteine sulfenic acids (Cys-SOH) which are thought to be one of the most prevalent cysteine modifications, and formation of these species reversibly alters protein function. However, the subtle balance between oxidative signaling and damage is still unclear because of a lack of sensitive, stable, readily detectable traps for these intermediates.

subject

contributor

Mukherjee, Rajeswari (author)

KING, STEPHEN B (committee chair)

JONES, PAUL B (committee member)

ALEXANDER, REBECCA W (committee member)

WELKER, MARK (committee member)

date

2015-06-23T08:36:01Z (accessioned)

2016-06-22T08:30:09Z (available)

2015 (issued)

degree

Chemistry (discipline)

embargo

2016-06-22 (terms)

identifier

http://hdl.handle.net/10339/57191 (uri)

language

en (iso)

publisher

Wake Forest University

title

SYNTHESIS OF SMALL MOLECULE PROBES FOR PROTEIN SULFENIC ACIDS

type

Dissertation