Item Details

abstract

Type 2 diabetes (T2D), a disease which affects more than 25% of adults over age 65 in the United States, is characterized by persistent elevations in blood glucose due to lower insulin production and elevated resistance to insulin’s actions in the peripheral tissues. T2D increases risk for a number of age-related comorbidities, including cardiovascular disease and cognitive decline. Risk of these comorbidities is thought to be influenced by both clinical factors, including differences in treatment, lifestyle, and environment, and genetic risk factors. This dissertation explores a number of potential contributors to these comorbidities in the family-based, T2D enriched Diabetes Heart Study cohort.

subject

aging

Diabetes Heart Study

genetics

contributor

Raffield, Laura Marie Tonks (author)

Bowden, Donald W (committee chair)

Howard, Timothy (committee member)

Hsu, Fang-Chi (committee member)

Nicklas, Barbara (committee member)

Ng, Maggie (committee member)

date

2015-08-25T08:35:22Z (accessioned)

2017-08-24T08:30:12Z (available)

2015 (issued)

degree

Molecular Genetics & Genomics (discipline)

embargo

2017-08-24 (terms)

identifier

http://hdl.handle.net/10339/57250 (uri)

language

en (iso)

publisher

Wake Forest University

title

Analysis of the genetic and epidemiological contributors to aging-related traits in the Diabetes Heart Study

type

Dissertation