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Naturally Derived Scaffolds for Treatment of Volumetric Muscle Loss

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abstract
Volumetric muscle loss (VML) is defined as the irrecoverable loss of function in skeletal muscle as a result of tissue loss. Herein, cell and growth factor loaded keratin hydrogels and Tissue Engineered Muscle Repair (TEMR) constructs consisting of cell seeded, cyclic stretched bladder acellular matrix (BAM), were investigated in VML injuries in which the overriding hypothesis was that these technologies would improve functional recovery and tissue morphology in otherwise irrecoverable injuries.
subject
Bladder Acellular Matrix
Keratin
Rodent Model
Skeletal Muscle
Tissue Engineering
Volumetric Muscle Loss
contributor
Baker, Hannah Besser (author)
Christ, George J. (committee chair)
Almeida-Porada, Graca (committee member)
Goldstein, Aaron (committee member)
Grange, Robert (committee member)
Kaplan, David (committee member)
Mohs, Aaron (committee member)
date
2015-08-25T08:35:30Z (accessioned)
2017-08-24T08:30:13Z (available)
2015 (issued)
degree
Biomedical Engineering (discipline)
embargo
2017-08-24 (terms)
identifier
http://hdl.handle.net/10339/57256 (uri)
language
en (iso)
publisher
Wake Forest University
title
Naturally Derived Scaffolds for Treatment of Volumetric Muscle Loss
type
Dissertation

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