Item Details

title

THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION

author

Jennings, Ryan

abstract

The human gammaherpesvirus Epstein-Barr virus (EBV) is associated with multiple forms of cancer. Suppressing gammaherpesvirus reactivation and latency is a potential therapeutic target in the prevention or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic and latent gammaherpesvirus infection, as demonstrated in the well-established murine model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 infection, and have been demonstrated to directly and indirectly support antiviral CD8+ T cell development and function in various murine viral infection models. Despite well-established roles for CD8+ T cells in controlling gammaherpesvirus infections, the mechanisms that govern the generation and enhancement of the gammaherpesvirus-specific CD8+ T response are unknown. This study was undertaken to evaluate the role of type I IFNs in MHV68-specific CD8+ T cell expansion, differentiation, and functionality utilizing a murine type I IFN receptor knockout strain (IFNAR1-/-).

subject

herpesviridae

MHV68

mice

peritoneum

rhadinovirus

contributor

Barton, Erik S (committee chair)

Cline, J. Mark (committee member)

Lyles, Doug S (committee member)

Haas, Karen M (committee member)

Grayson, Jason M (committee member)

date

2015-08-25T08:35:34Z (accessioned)

2015-08-25T08:35:34Z (available)

2015 (issued)

degree

Microbiology & Immunology (discipline)

identifier

http://hdl.handle.net/10339/57262 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation