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THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION

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title
THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION
author
Jennings, Ryan
abstract
The human gammaherpesvirus Epstein-Barr virus (EBV) is associated with multiple forms of cancer. Suppressing gammaherpesvirus reactivation and latency is a potential therapeutic target in the prevention or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic and latent gammaherpesvirus infection, as demonstrated in the well-established murine model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 infection, and have been demonstrated to directly and indirectly support antiviral CD8+ T cell development and function in various murine viral infection models. Despite well-established roles for CD8+ T cells in controlling gammaherpesvirus infections, the mechanisms that govern the generation and enhancement of the gammaherpesvirus-specific CD8+ T response are unknown. This study was undertaken to evaluate the role of type I IFNs in MHV68-specific CD8+ T cell expansion, differentiation, and functionality utilizing a murine type I IFN receptor knockout strain (IFNAR1-/-).
subject
herpesviridae
MHV68
mice
peritoneum
rhadinovirus
contributor
Barton, Erik S (committee chair)
Cline, J. Mark (committee member)
Lyles, Doug S (committee member)
Haas, Karen M (committee member)
Grayson, Jason M (committee member)
date
2015-08-25T08:35:34Z (accessioned)
2015-08-25T08:35:34Z (available)
2015 (issued)
degree
Microbiology & Immunology (discipline)
identifier
http://hdl.handle.net/10339/57262 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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