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Determining Single Fiber Nanomechanical Properties of Electrospun Protein Fibers and Modified Fibrin Fibers Using Atomic Force Microscopy

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title
Determining Single Fiber Nanomechanical Properties of Electrospun Protein Fibers and Modified Fibrin Fibers Using Atomic Force Microscopy
author
Baker, Stephen Robert
abstract
The extracellular matrix is comprised mostly of collagen, the most abundant protein in the body. This protein helps to provide the structural support for various tissues such as skin, muscles, tendons, and even heart valves and blood vessels. Fibrinogen is the most abundant protein found in blood plasma. After exposure to thrombin, it is converted to fibrin, and provides the structural support of a blood clot. These natural polymers, along with synthetic polymers, can be synthesized outside the body by a process known as electrospinning. Electrospinning can be used to make nanofibers which form the macrostructure scaffold to be tailored to specific applications. The mechanical properties
subject
Atomic Force Microscopy
Electrospinning
Fibrin
Nanomechanics
Single Fiber
contributor
Guthold, Martin (committee chair)
Hall, Adam (committee member)
Bonin, Keith (committee member)
Holzwarth, George (committee member)
Kim-Shapiro, Daniel (committee member)
date
2015-08-25T08:35:35Z (accessioned)
2016-02-24T09:30:09Z (available)
2015 (issued)
degree
Physics (discipline)
embargo
2016-02-24 (terms)
identifier
http://hdl.handle.net/10339/57263 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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