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Single Fibrin Fiber Mechanical Properties and Lysis

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abstract
Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the last few years the mechanical properties of fibrin fibers, such as their modulus, elasticity and extensibility, have been determined using samples formed from purified fibrinogen. In my work, presented in this dissertation, I initiated study on the more complex and more physiologically relevant fibrin fibers formed from plasma samples, in an effort to find relationships between single fibrin fiber mechanical properties and disease states.
subject
fibrin fiber
lysis
mechanical property
contributor
LI, WEI (author)
Guthold, Martin (committee chair)
Marrs, Glen (committee member)
Bonin, Keith (committee member)
Macosko, Jed (committee member)
Williams, Richard (committee member)
date
2015-08-25T08:35:35Z (accessioned)
2017-08-24T08:30:13Z (available)
2015 (issued)
degree
Physics (discipline)
embargo
2017-08-24 (terms)
identifier
http://hdl.handle.net/10339/57266 (uri)
language
en (iso)
publisher
Wake Forest University
title
Single Fibrin Fiber Mechanical Properties and Lysis
type
Dissertation

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