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Salivary Reduction of Dietary Nitrate

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abstract
Nitric oxide (NO) is an important cellular signaling molecule known mostly for its vasodilatative effects. Nitrate (NO3-) acts as an important NO source through reductive physiological pathways. Basal plasma NO3- levels are a sum of the oxidation of endogenous NO and ingested dietary NO3-. Approximately 25% of dietary NO3- is recovered by the salivary glands and concentrated up to 20-fold in saliva. Humans possess symbiotic NO3- reductase activity from the anaerobic bacteria (Actinomyces and Veillonella) species found in the tongue’s cleft. Preliminary genomic analyses of these species indicate the lack of nitrite (NO2-) reductase ortholog genes suggesting dissimilatory NO3- reduction. The goal of Aim 1 of this research was to investigate and fully characterize the reduction of dietary NO3- to reduced nitrogen oxides in the oral cavity.
subject
Dietary Nitrate
Nitrate
Nitric Oxide
Nitrite
Nitrogen Oxide
Saliva
contributor
Clodfelter, William Howard Craig (author)
King, Stephen B (committee chair)
Kim-Shapiro, Daniel (committee member)
Welker, Mark E (committee member)
DosSantos, Patricia (committee member)
Bierbach, Ulrich (committee member)
date
2015-08-25T08:35:36Z (accessioned)
2016-08-24T08:30:10Z (available)
2015 (issued)
degree
Chemistry (discipline)
embargo
2016-08-24 (terms)
identifier
http://hdl.handle.net/10339/57269 (uri)
language
en (iso)
publisher
Wake Forest University
title
Salivary Reduction of Dietary Nitrate
type
Dissertation

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