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Quorum Signaling and Biofilm Antibiotic Resistance Phenotypes of Nontypeable Haemophilus influenzae Clinical Isolates

Electronic Theses and Dissertations

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abstract
The genetically and phenotypically diverse bacterium nontypeable Haemophilus influenzae (NTHi) is a leading cause of otitis media (OM). This disease affects children around the world. Treatment is complicated by the ability of the bacteria to form biofilms in which they are more tolerant to antimicrobials. Developing a better understanding of biofilm antibiotic resistance and possible roles for cell-cell communication may lead to new therapeutic options. While many fascinating findings come from studies using NTHi lab strains, the results from any one strain do not necessarily represent the entire population.
subject
Antibiotics
Biofilm
Haemophilus influenzae
Quorum signaling
contributor
Reimche, Jennifer (author)
Swords, William E (committee chair)
Claiborne, Al (committee member)
Ornelles, David (committee member)
Richardson, Stephen (committee member)
Westcott, Marlena (committee member)
date
2015-08-25T08:35:39Z (accessioned)
2017-08-24T08:30:12Z (available)
2015 (issued)
degree
Microbiology & Immunology (discipline)
embargo
2017-08-24 (terms)
identifier
http://hdl.handle.net/10339/57274 (uri)
language
en (iso)
publisher
Wake Forest University
title
Quorum Signaling and Biofilm Antibiotic Resistance Phenotypes of Nontypeable Haemophilus influenzae Clinical Isolates
type
Dissertation

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