Synthesis and evaluation of N6-substituted azide- and alkyne-bearing N-mustard analogs of S-adenosyl-l-methionine
Comstock-Ferguson, Lindsay R.
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Item Details
- abstract
- The synthesis of a family of N-mustard analogs of S-adenosyl-l-methionine (SAM) containing azides and alkynes at the N6-position of the adenosine base has been accomplished from commercially available inosine. Further biochemical analysis of these analogs indicates successful modification of pUC19 plasmid DNA in an enzyme-dependent fashion with DNA methyltransferases M.TaqI and M.HhaI.
- Financial support of this research from Wake Forest University and the National Science Foundation (CHE-1307425) are gratefully acknowledged. (sponsorship)
- subject
- S-Adenosyl-l-methionine
- DNA methyltransferase
- SAM analog
- N-Mustard
- citation
- 34 (issue)
- 70 (volume)
- contributor
- date
- 2015-10-09T16:05:59Z (accessioned)
- 2015-10-09T16:05:59Z (available)
- 2014 (issued)
- http://dx.doi.org/10.1016/j.tet.2014.05.055 (doi)
- identifier
- http://hdl.handle.net/10339/57363 (uri)
- publisher
- Elsevier
- rights
- https://creativecommons.org/licenses/by-nc-nd/3.0/ (uri)
- source
- Tetrahedron
- title
- Synthesis and evaluation of N6-substituted azide- and alkyne-bearing N-mustard analogs of S-adenosyl-l-methionine
- type
- Article