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Changes in global and regional modularity associated with increasing working memory load

Dagenbach, Dale

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abstract
Using graph theory measures common to complex network analyses of neuroimaging data, the objective of this study was to explore the effects of increasing working memory processing load on functional brain network topology in a cohort of young adults. Measures of modularity in complex brain networks quantify how well a network is organized into densely interconnected communities. We investigated changes in both the large-scale modular organization of the functional brain network as a whole and regional changes in modular organization as demands on working memory increased from n = 1 to n = 2 on the standard n-back task. We further investigated the relationship between modular properties across working memory load conditions and behavioral performance. Our results showed that regional modular organization within the default mode and working memory circuits significantly changed from 1-back to 2-back task conditions. However, the regional modular organization was not associated with behavioral performance. Global measures of modular organization did not change with working memory load but were associated with individual variability in behavioral performance. These findings indicate that regional and global network properties are modulated by different aspects of working memory under increasing load conditions. These findings highlight the importance of assessing multiple features of functional brain network topology at both global and regional scales rather than focusing on a single network property.
This work was partially supported by the Wake Forest Older Americans Independence Center (P3021332), the Sticht Center on Aging at Wake Forest School of Medicine, and the Translational Science Center at Wake Forest University. (sponsorship)
subject
working memory
working memory load
n-back
graph theory
fMRI
complex network
modularity
citation
8 (volume)
contributor
Stanley, Matthew L. (author)
Dagenbach, Dale (author)
Lyday, Robert G. (author)
Burdette, Jonathan H. (author)
Laurienti, Paul J. (author)
date
2015-10-09T18:10:24Z (accessioned)
2015-10-09T18:10:24Z (available)
2014 (issued)
http://dx.doi.org/10.3389/fnhum.2014.00954 (doi)
identifier
http://hdl.handle.net/10339/57376 (uri)
publisher
Frontiers
rights
https://creativecommons.org/licenses/by/3.0/ (uri)
source
Frontiers in Human Neuroscience
title
Changes in global and regional modularity associated with increasing working memory load
type
Article

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