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INTERDEPENDENT REGULATION OF METABOLISM AND INFLAMMATION IN HUMAN MONOCYTES

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title
INTERDEPENDENT REGULATION OF METABOLISM AND INFLAMMATION IN HUMAN MONOCYTES
author
Millet, Patrick
abstract
Sepsis is serious medical condition which kills millions of people worldwide each year. In the United States, severe sepsis has a mortality rate of 20-30%, with an annual cost of over $25 billion. Modern advances in supportive care have brought the mortality rate down to its current level, however there is currently no molecular-based treatment available for sepsis. Many treatments have been tested in clinical trials, but none have proven reliably beneficial. These treatments, however, seldom accounted for the fact sepsis has distinct stages with distinct immunometabolic profiles. Early sepsis is marked by inflammation and glycolysis, while late sepsis is marked by immune suppression and fatty acid oxidation. As an increasing body of data suggests, these metabolic and immune states may be interdependent.
subject
Inflammation
Metabolism
Mitochondria
Monocytes
RNA biology
Sepsis
contributor
McCall, Charles E (committee chair)
McPhail, Linda (committee member)
Yoza, Barbara (committee member)
Alexander-Miller, Martha (committee member)
Molina, Anthony (committee member)
date
2016-01-11T09:35:18Z (accessioned)
2016-07-10T08:30:10Z (available)
2015 (issued)
degree
Molecular Genetics & Genomics (discipline)
embargo
2016-07-10 (terms)
identifier
http://hdl.handle.net/10339/57421 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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