Item Details

abstract

Sepsis is serious medical condition which kills millions of people worldwide each year. In the United States, severe sepsis has a mortality rate of 20-30%, with an annual cost of over $25 billion. Modern advances in supportive care have brought the mortality rate down to its current level, however there is currently no molecular-based treatment available for sepsis. Many treatments have been tested in clinical trials, but none have proven reliably beneficial. These treatments, however, seldom accounted for the fact sepsis has distinct stages with distinct immunometabolic profiles. Early sepsis is marked by inflammation and glycolysis, while late sepsis is marked by immune suppression and fatty acid oxidation. As an increasing body of data suggests, these metabolic and immune states may be interdependent.

subject

Inflammation

Metabolism

Mitochondria

Monocytes

RNA biology

Sepsis

contributor

Millet, Patrick (author)

McCall, Charles E (committee chair)

McPhail, Linda (committee member)

Yoza, Barbara (committee member)

Alexander-Miller, Martha (committee member)

Molina, Anthony (committee member)

date

2016-01-11T09:35:18Z (accessioned)

2016-07-10T08:30:10Z (available)

2015 (issued)

degree

Molecular Genetics & Genomics (discipline)

embargo

2016-07-10 (terms)

identifier

http://hdl.handle.net/10339/57421 (uri)

language

en (iso)

publisher

Wake Forest University

title

INTERDEPENDENT REGULATION OF METABOLISM AND INFLAMMATION IN HUMAN MONOCYTES

type

Dissertation