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ELUCIDATING AMPHETAMINE ACTIONS AT THE DOPAMINE TERMINAL: POTENTIAL FOR COCAINE ADDICTION TREATMENT

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abstract
The behavioral and neurochemical effects of amphetamine have been studied since the beginnings of neuroscience; however, many questions still remain as to its precise mechanisms of action on neurotransmission, and the resulting effects on behavior. Given that amphetamine is one of the most widely prescribed stimulants, and is also abused off-label, it is critical to understand the mechanisms of amphetamine actions to drive the design of improved pharmacotherapeutics with high clinical efficacy and limited addiction potential. The work contained in this dissertation is focused on elucidating amphetamine’s actions on dopamine neurotransmission that underlie its therapeutic actions as well as its abuse potential.
subject
addiction
behavioral economics
dopamine
nucleus accumbens
self-administration
voltammetry
contributor
Siciliano, Cody A. (author)
Jones, Sara R (committee chair)
Martin, Thomas J (committee member)
Porrino, Linda J (committee member)
McCool, Brian A (committee member)
Nader, Michael A (committee member)
Weiner, Jeffrey L (committee member)
date
2016-01-11T09:35:28Z (accessioned)
2018-01-10T09:30:10Z (available)
2015 (issued)
degree
Physiology and Pharmacology (discipline)
embargo
2018-01-10 (terms)
identifier
http://hdl.handle.net/10339/57442 (uri)
language
en (iso)
publisher
Wake Forest University
title
ELUCIDATING AMPHETAMINE ACTIONS AT THE DOPAMINE TERMINAL: POTENTIAL FOR COCAINE ADDICTION TREATMENT
type
Dissertation

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