Item Details

title

ELUCIDATING AMPHETAMINE ACTIONS AT THE DOPAMINE TERMINAL: POTENTIAL FOR COCAINE ADDICTION TREATMENT

author

Siciliano, Cody A.

abstract

The behavioral and neurochemical effects of amphetamine have been studied since the beginnings of neuroscience; however, many questions still remain as to its precise mechanisms of action on neurotransmission, and the resulting effects on behavior. Given that amphetamine is one of the most widely prescribed stimulants, and is also abused off-label, it is critical to understand the mechanisms of amphetamine actions to drive the design of improved pharmacotherapeutics with high clinical efficacy and limited addiction potential. The work contained in this dissertation is focused on elucidating amphetamine’s actions on dopamine neurotransmission that underlie its therapeutic actions as well as its abuse potential.

subject

addiction

behavioral economics

dopamine

nucleus accumbens

self-administration

voltammetry

contributor

Jones, Sara R (committee chair)

Martin, Thomas J (committee member)

Porrino, Linda J (committee member)

McCool, Brian A (committee member)

Nader, Michael A (committee member)

Weiner, Jeffrey L (committee member)

date

2016-01-11T09:35:28Z (accessioned)

2018-01-10T09:30:10Z (available)

2015 (issued)

degree

Physiology and Pharmacology (discipline)

embargo

2018-01-10 (terms)

identifier

http://hdl.handle.net/10339/57442 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation