Item Details

abstract

Dopamine is the most common neurotransmitter in the mammalian brain and is a key modulator of reward-related behaviors. Through the use of animal models, the dopaminergic system has been implicated in several neuropsychiatric disorders. Furthermore, the application of genetic technologies has helped uncover how modulation of dopaminergic signaling leads to modification of normal behavior and contributes to negative phenotypes and symptoms associated with diseases like attention-deficit/hyperactivity disorder, cocaine dependence, and obesity. This dissertation explores a number of behaviors, learned and unconditioned, and the contribution of dopaminergic neurotransmission to each by using both human and non-human primates as subjects.

subject

Cognition

dopa decarboxylase

Dopamine

Dopamine D3 receptors

Type 2 diabetes

yawning

contributor

Martelle, Susan Elizabeth (author)

Bowden, Donald W (committee chair)

Allred, Nicholette D (committee member)

Howard, Timothy (committee member)

Jorgensen, Matthew J (committee member)

Weiner, Jeffrey (committee member)

date

2016-05-21T08:35:27Z (accessioned)

2016-11-20T09:30:12Z (available)

2016 (issued)

degree

Physiology and Pharmacology (discipline)

embargo

2016-11-20 (terms)

identifier

http://hdl.handle.net/10339/59260 (uri)

language

en (iso)

publisher

Wake Forest University

title

A study of the neuropharmacology and genetics of dopamine: using common, preclinical behavioral techniques, cognitive batteries, and genetic analyses to unravel the dopaminergic system

type

Dissertation