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Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis

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abstract
Selective serotonin reuptake inhibitor (SSRI) antidepressants, widely prescribed for depression and other disorders, have been associated with increased ischemic stroke risk in several observational studies. Previously the Shively lab has reported that long-term SSRI treatment and depression independently increased coronary artery atherosclerosis; however effects on carotid artery atherosclerosis, a precursor to ischemic stroke, are unknown. Whether SSRI use affects risk factors for stroke and atherosclerosis is also unclear as results from clinical trials and observational studies are mixed. The overall objective of this dissertation research was to determine the effects of long-term SSRI treatment on carotid artery atherosclerosis and associated risk factors using a translational nonhuman primate model of depression.
subject
atherosclerosis
depression
monkey
nonhuman primate
SSRI
stroke
contributor
Metzler, Marnie Silverstein (author)
Shively, Carol A (committee chair)
Nader, Michael A (committee member)
Appt, Susan E (committee member)
Caudell, David L (committee member)
Register, Thomas C (committee member)
date
2016-05-21T08:35:29Z (accessioned)
2016-05-21T08:35:29Z (available)
2016 (issued)
degree
Physiology and Pharmacology (discipline)
identifier
http://hdl.handle.net/10339/59263 (uri)
language
en (iso)
publisher
Wake Forest University
title
Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis
type
Dissertation

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