Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis
Electronic Theses and Dissertations
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Item Details
- abstract
- Selective serotonin reuptake inhibitor (SSRI) antidepressants, widely prescribed for depression and other disorders, have been associated with increased ischemic stroke risk in several observational studies. Previously the Shively lab has reported that long-term SSRI treatment and depression independently increased coronary artery atherosclerosis; however effects on carotid artery atherosclerosis, a precursor to ischemic stroke, are unknown. Whether SSRI use affects risk factors for stroke and atherosclerosis is also unclear as results from clinical trials and observational studies are mixed. The overall objective of this dissertation research was to determine the effects of long-term SSRI treatment on carotid artery atherosclerosis and associated risk factors using a translational nonhuman primate model of depression.
- subject
- atherosclerosis
- depression
- monkey
- nonhuman primate
- SSRI
- stroke
- contributor
- Shively, Carol A (committee chair)
- Nader, Michael A (committee member)
- Appt, Susan E (committee member)
- Caudell, David L (committee member)
- Register, Thomas C (committee member)
- date
- 2016-05-21T08:35:29Z (accessioned)
- 2016-05-21T08:35:29Z (available)
- 2016 (issued)
- degree
- Physiology and Pharmacology (discipline)
- identifier
- http://hdl.handle.net/10339/59263 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis
- type
- Dissertation