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Studies in Peroxiredoxin Hyperoxidation Sensitivity

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abstract
Prxs are a family of antioxidant proteins that are the predominant peroxidase within the cell. This thesis research focuses on the structure and biochemistry of peroxiredoxins (Prx) and their sensitivity to inactivation by their own substrate, in a process called hyperoxidation. Hyperoxidation sensitivity is important to study because Prxs are implicated in many different diseases. For example, Prxs contribute to chemo- and radioresistance in cancers, so by sensitizing a Prx to inactivation, it may be possible to resensitize cancer cells to therapy.
subject
crystallography
kinetics
oxidative stress
peroxiredoxins
redox biology
signaling
contributor
Bolduc, Jesalyn (author)
Lowther, W. Todd (committee chair)
Hollis, Thomas (committee member)
Poole, Leslie (committee member)
Lyles, Douglas (committee member)
date
2016-05-21T08:35:36Z (accessioned)
2018-05-20T08:30:11Z (available)
2016 (issued)
degree
Biochemistry and Molecular Biology (discipline)
embargo
2018-05-20 (terms)
identifier
http://hdl.handle.net/10339/59274 (uri)
language
en (iso)
publisher
Wake Forest University
title
Studies in Peroxiredoxin Hyperoxidation Sensitivity
type
Dissertation

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