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PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES

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abstract
Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an in-depth understanding of the role of PD-1 and PD-1 ligands (PD-L) in B cell regulation. This dissertation specifically ascertains the role of PD-1 and PD-L in the regulation of natural Ab production and also adaptive Ab responses to T cell-independent type 2 (TI-2) antigens (Ag).
subject
B-1 cells
PD-1
PD-L1
PD-L2
Phosphorylcholine
Polysaccharide
contributor
McKay, Jerome Thomas (author)
Haas, Karen M (committee chair)
Claiborne, Al (committee member)
Deora, Rajendar (committee member)
Alexander-Miller, Martha (committee member)
Swords, William Edward (committee member)
date
2016-05-21T08:35:41Z (accessioned)
2016 (issued)
degree
Microbiology & Immunology (discipline)
2021-05-04 (liftdate)
embargo
2021-05-04 (terms)
identifier
http://hdl.handle.net/10339/59291 (uri)
language
en (iso)
publisher
Wake Forest University
title
PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES
type
Dissertation

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