PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES
Electronic Theses and Dissertations
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- abstract
- Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an in-depth understanding of the role of PD-1 and PD-1 ligands (PD-L) in B cell regulation. This dissertation specifically ascertains the role of PD-1 and PD-L in the regulation of natural Ab production and also adaptive Ab responses to T cell-independent type 2 (TI-2) antigens (Ag).
- subject
- B-1 cells
- PD-1
- PD-L1
- PD-L2
- Phosphorylcholine
- Polysaccharide
- contributor
- Haas, Karen M (committee chair)
- Claiborne, Al (committee member)
- Deora, Rajendar (committee member)
- Alexander-Miller, Martha (committee member)
- Swords, William Edward (committee member)
- date
- 2016-05-21T08:35:41Z (accessioned)
- 2016 (issued)
- degree
- Microbiology & Immunology (discipline)
- 2021-05-04 (liftdate)
- embargo
- 2021-05-04 (terms)
- identifier
- http://hdl.handle.net/10339/59291 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES
- type
- Dissertation