Item Details

abstract

Orthostatic Intolerance (OI) is a type of autonomic dysfunction affecting >500,000 adults and children in the United States. Upon standing, subjects with OI have impaired blood pressure (BP) regulation that leads to debilitating symptoms of dizziness, fatigue, nausea, and fainting. The development of OI is poorly understood and a variety of cardiovascular responses occur with standing including exaggerated tachycardia, hypotension, and syncope. OI is associated with functional gastrointestinal (GI) symptoms, specifically chronic nausea, in children and exaggerated neurohumoral responses in adults. The heterogeneity in symptoms of autonomic dysfunction highlights the importance of defining phenotypic profiles to ensure effective management and treatment of the patient-specific cardiovascular (CV) and gastrointestinal (GI) symptoms. To do this, it is critical to identify key factors that regulate autonomic outflow in supine and upright positions in OI. To this end, our goals were to define phenotypes of OI and chronic nausea in children based upon measures of hemodynamic and neurohumoral responses to orthostatic challenge and to evaluate the relationship between supine cerebral metabolites to autonomic function.

subject

arginine vasopressin

autonomic nervous system

magnetic resonance spectroscopy

nausea

orthostatic intolerance

pediatric

contributor

Wagoner, Ashley L (author)

Diz, Debra I (committee chair)

Milligan, Carolanne E (committee member)

Fortunato, John E (committee member)

Shaltout, Hossam A (committee member)

Mack, David L (committee member)

date

2016-05-21T08:35:42Z (accessioned)

2018-05-20T08:30:13Z (available)

2016 (issued)

degree

Neuroscience (discipline)

embargo

2018-05-20 (terms)

identifier

http://hdl.handle.net/10339/59293 (uri)

language

en (iso)

publisher

Wake Forest University

title

ALTERED HEMODYNAMIC, NEUROHUMORAL, AND BRAIN METABOLITE PROFILES IN CHILDREN WITH ORTHOSTATIC INTOLERANCE AND CHRONIC NAUSEA

type

Dissertation