Home WakeSpace Scholarship › Electronic Theses and Dissertations

ALTERED HEMODYNAMIC, NEUROHUMORAL, AND BRAIN METABOLITE PROFILES IN CHILDREN WITH ORTHOSTATIC INTOLERANCE AND CHRONIC NAUSEA

Electronic Theses and Dissertations

Item Files

Item Details

abstract
Orthostatic Intolerance (OI) is a type of autonomic dysfunction affecting >500,000 adults and children in the United States. Upon standing, subjects with OI have impaired blood pressure (BP) regulation that leads to debilitating symptoms of dizziness, fatigue, nausea, and fainting. The development of OI is poorly understood and a variety of cardiovascular responses occur with standing including exaggerated tachycardia, hypotension, and syncope. OI is associated with functional gastrointestinal (GI) symptoms, specifically chronic nausea, in children and exaggerated neurohumoral responses in adults. The heterogeneity in symptoms of autonomic dysfunction highlights the importance of defining phenotypic profiles to ensure effective management and treatment of the patient-specific cardiovascular (CV) and gastrointestinal (GI) symptoms. To do this, it is critical to identify key factors that regulate autonomic outflow in supine and upright positions in OI. To this end, our goals were to define phenotypes of OI and chronic nausea in children based upon measures of hemodynamic and neurohumoral responses to orthostatic challenge and to evaluate the relationship between supine cerebral metabolites to autonomic function.
subject
arginine vasopressin
autonomic nervous system
magnetic resonance spectroscopy
nausea
orthostatic intolerance
pediatric
contributor
Wagoner, Ashley L (author)
Diz, Debra I (committee chair)
Milligan, Carolanne E (committee member)
Fortunato, John E (committee member)
Shaltout, Hossam A (committee member)
Mack, David L (committee member)
date
2016-05-21T08:35:42Z (accessioned)
2018-05-20T08:30:13Z (available)
2016 (issued)
degree
Neuroscience (discipline)
embargo
2018-05-20 (terms)
identifier
http://hdl.handle.net/10339/59293 (uri)
language
en (iso)
publisher
Wake Forest University
title
ALTERED HEMODYNAMIC, NEUROHUMORAL, AND BRAIN METABOLITE PROFILES IN CHILDREN WITH ORTHOSTATIC INTOLERANCE AND CHRONIC NAUSEA
type
Dissertation

Usage Statistics