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THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES

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abstract
Background: Genetic studies in asthma and COPD have identified common genetic variants that explain a small proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such as African Americans where a higher percentage of African ancestry was associated with lower lung function. Rare genetic variants (allele frequency <0.05) with strong effects and genetic ancestry have the potential to be genetic factors that determine drug response and severity in asthma and COPD.
subject
asthma
COPD
genetics
pharmacogenetics
rare variant
single nucleotide polymorphism
contributor
Ortega, Victor Enrique (author)
Meyers, Deborah A (committee chair)
Bleecker, Eugene R (committee member)
Hawkins, Gregory A (committee member)
Bowden, Donald W (committee member)
Howard, Timothy D (committee member)
date
2016-08-25T08:35:19Z (accessioned)
2016 (issued)
degree
Molecular Medicine and Translational Science (discipline)
2021-08-18 (liftdate)
embargo
2021-08-18 (terms)
identifier
http://hdl.handle.net/10339/62631 (uri)
language
en (iso)
publisher
Wake Forest University
title
THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES
type
Dissertation

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