THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES
Electronic Theses and Dissertations
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Item Details
- abstract
- Background: Genetic studies in asthma and COPD have identified common genetic variants that explain a small proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such as African Americans where a higher percentage of African ancestry was associated with lower lung function. Rare genetic variants (allele frequency <0.05) with strong effects and genetic ancestry have the potential to be genetic factors that determine drug response and severity in asthma and COPD.
- subject
- asthma
- COPD
- genetics
- pharmacogenetics
- rare variant
- single nucleotide polymorphism
- contributor
- Meyers, Deborah A (committee chair)
- Bleecker, Eugene R (committee member)
- Hawkins, Gregory A (committee member)
- Bowden, Donald W (committee member)
- Howard, Timothy D (committee member)
- date
- 2016-08-25T08:35:19Z (accessioned)
- 2021-08-18T08:30:13Z (available)
- 2016 (issued)
- degree
- Molecular Medicine and Translational Science (discipline)
- embargo
- 2021-08-18 (terms)
- identifier
- http://hdl.handle.net/10339/62631 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES
- type
- Dissertation