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Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity

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abstract
Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare mechanical properties of metastatic and non-metastatic cells, and to develop a method for testing the effect of microenvironment elasticity on cancer cell migration.
subject
breast cancer cells
collagen
elasticity
mechanical properties
microrheology
migration
contributor
Smelser, Amanda M. (author)
Macosko, Jed C (committee chair)
Cho, Samuel S (committee member)
Lyles, Doug S (committee member)
Hantgan, Roy (committee member)
date
2016-08-25T08:35:19Z (accessioned)
2016-08-25T08:35:19Z (available)
2016 (issued)
degree
Biochemistry and Molecular Biology (discipline)
identifier
http://hdl.handle.net/10339/62632 (uri)
language
en (iso)
publisher
Wake Forest University
title
Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity
type
Dissertation

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