Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity
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- abstract
- Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare mechanical properties of metastatic and non-metastatic cells, and to develop a method for testing the effect of microenvironment elasticity on cancer cell migration.
- subject
- breast cancer cells
- collagen
- elasticity
- mechanical properties
- microrheology
- migration
- contributor
- Macosko, Jed C (committee chair)
- Cho, Samuel S (committee member)
- Lyles, Doug S (committee member)
- Hantgan, Roy (committee member)
- date
- 2016-08-25T08:35:19Z (accessioned)
- 2016-08-25T08:35:19Z (available)
- 2016 (issued)
- degree
- Biochemistry and Molecular Biology (discipline)
- identifier
- http://hdl.handle.net/10339/62632 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity
- type
- Dissertation