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THE EFFECTS OF PARKINSON’S DISEASE AND ASSOCIATED TREATMENTS ON SACCADIC EYE MOVEMENTS

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abstract
Eye movements are used as a biomarker of neuropsychiatric and neurological function because they are highly sensitive to cognitive state and impairment. For this reason, eye movements have been used to study Parkinson’s disease in order to bypass the distal limb motor deficits seen with disease progression. This study aimed to use eye movements to correlate disease severity with performance on a battery of cognitive tasks, and ultimately elucidate some of the mechanisms behind the disease. Our initial results were consistent with previous literature, and we found changes in reaction time for patients compared to controls, as well as the same patients on and off medication. Performance was increased on-medication state for the delayed-saccade (DST). Trends in an increase in performance for the memory-guided (MGS) and antisaccade tasks were also seen. A perceptual vortex was uncovered in the antisaccade task, supporting the idea that decrease in cognitive control can impair one’s ability to overcome the sensory pull of a salient stimulus.
subject
contributor
Rogers, Emily (author)
ul Haq, Ihtsham (committee chair)
Stanford, Terrence (committee member)
Salinas, Emilio (committee member)
date
2016-08-25T08:35:20Z (accessioned)
2017-08-19T08:30:10Z (available)
2016 (issued)
degree
Neuroscience (discipline)
embargo
2017-08-19 (terms)
identifier
http://hdl.handle.net/10339/62636 (uri)
language
en (iso)
publisher
Wake Forest University
title
THE EFFECTS OF PARKINSON’S DISEASE AND ASSOCIATED TREATMENTS ON SACCADIC EYE MOVEMENTS
type
Thesis

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