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Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function

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abstract
Infection with influenza A virus (IAV) can lead to increased susceptibility to subsequent bacterial infection, often with Streptococcus pneumoniae (Spn). Clinical and experimental data indicate increased disease severity when a coinfecting agent is present during IAV infection, indicating the need to understand how the presence of a coinfecting pathogen can modulate the ongoing adaptive CD8+ T cell response to IAV.
subject
Coinfection
Immune regulation
Influenza
pneumococcus
contributor
Blevins, Lance Kendall (author)
Alexander-Miller, Martha A (committee chair)
Lyles, Douglas S (committee member)
Haas, Karen M (committee member)
Grayson, Jason M (committee member)
Swords, William E (committee member)
Parsonage, Derek (committee member)
date
2016-08-25T08:35:23Z (accessioned)
2018-08-19T08:30:09Z (available)
2016 (issued)
degree
Microbiology & Immunology (discipline)
embargo
2018-08-19 (terms)
identifier
http://hdl.handle.net/10339/62646 (uri)
language
en (iso)
publisher
Wake Forest University
title
Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function
type
Dissertation

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