Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function
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- abstract
- Infection with influenza A virus (IAV) can lead to increased susceptibility to subsequent bacterial infection, often with Streptococcus pneumoniae (Spn). Clinical and experimental data indicate increased disease severity when a coinfecting agent is present during IAV infection, indicating the need to understand how the presence of a coinfecting pathogen can modulate the ongoing adaptive CD8+ T cell response to IAV.
- subject
- Coinfection
- Immune regulation
- Influenza
- pneumococcus
- contributor
- Alexander-Miller, Martha A (committee chair)
- Lyles, Douglas S (committee member)
- Haas, Karen M (committee member)
- Grayson, Jason M (committee member)
- Swords, William E (committee member)
- Parsonage, Derek (committee member)
- date
- 2016-08-25T08:35:23Z (accessioned)
- 2018-08-19T08:30:09Z (available)
- 2016 (issued)
- degree
- Microbiology & Immunology (discipline)
- embargo
- 2018-08-19 (terms)
- identifier
- http://hdl.handle.net/10339/62646 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function
- type
- Dissertation