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Coronary Artery Calcium and Incident Stroke in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort

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abstract
In the published literature, coronary artery calcium (CAC) score is a well-documented independent predictor of incident coronary heart disease (CHD) events, including myocardial infarction, death related to cardiovascular disease, and cardiac arrest.22 In addition to the progression of disease in the coronary arteries, CAC has also been associated with the progression of atherosclerotic disease in the cerebrovascular system and has been shown to predict the presence of significant/overt carotid stenosis in an asymptomatic cohort.11 Despite the relationship between carotid stenosis and risk of future stroke, the prognostic value of CAC to predict incident stroke remains unclear. The MESA cohort provides a unique opportunity to study the association between CAC and the risk of incident stroke as the cohort contains over 6800 participants with no known coronary or cerebrovascular disease. The participants have been followed for over 10 years and a wide range of data has been collected including demographics, assessment of cardiovascular risk factors, and adjudication for various clinical outcomes. Using the available MESA participant risk factor and outcome data, the purpose of this thesis is to examine the relationship between CAC score and the risk of incident stroke in a multi-ethnic population free of cerebrovascular disease.
subject
CAC
gender
MESA
stroke
contributor
Owen, Ashleigh Anne (author)
Yeboah, Joseph (committee chair)
Cartwright, Michael (committee member)
Pajewski, Nicholas (committee member)
Herrington, David M (committee member)
date
2016-08-25T08:35:26Z (accessioned)
2016-08-25T08:35:26Z (available)
2016 (issued)
degree
Clinical and Population Translational Sciences (discipline)
identifier
http://hdl.handle.net/10339/62649 (uri)
language
en (iso)
publisher
Wake Forest University
title
Coronary Artery Calcium and Incident Stroke in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort
type
Thesis

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