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MUNC13 PROTEINS REGULATE STRAIN-DEPENDENT EFFECTS OF ETHANOL-MEDIATED INHIBITION OF SYNAPTIC VESICLE RECYCLING

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title
MUNC13 PROTEINS REGULATE STRAIN-DEPENDENT EFFECTS OF ETHANOL-MEDIATED INHIBITION OF SYNAPTIC VESICLE RECYCLING
author
Gioia, Dominic Andrew
abstract
Alcoholism is a chronically relapsing disorder characterized by an inability to remain abstinent from alcohol for prolonged periods of time. One of the major factors contributing to relapse is the development of profound anxiety during abstinence. Our lab has previously demonstrated that chronic exposure to alcohol and subsequent withdrawal leads to long-term adaptations in glutamatergic transmission within the basolateral amygdala (BLA). We have also demonstrated that this hyperexcitable state contributes to the expression of withdrawal related anxiogenesis and can be ameliorated by glutamatergic antagonists. However, it remains unclear how acute exposure to alcohol produces long-term changes in BLA glutamatergic transmission.
subject
Alcohol
anxiety
basolateral amygdala
glutamate
Munc13
Presynaptic
contributor
McCool, Brian A (committee chair)
Stanford, Terrence (committee member)
Jones, Sara (committee member)
Martin, Thomas J (committee member)
Weiner, Jeff (committee member)
date
2017-01-14T09:35:17Z (accessioned)
2018-01-13T09:30:09Z (available)
2016 (issued)
degree
Neuroscience (discipline)
embargo
2018-01-13 (terms)
identifier
http://hdl.handle.net/10339/64171 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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