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REGULATION OF C-MET RECEPTOR TYROSINE KINASE SIGNALING BY ANGIOTENSIN-(1-7) IN TRIPLE NEGATIVE BREAST CANCER

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abstract
Breast cancer remains a devastating disease, negatively impacting the lives of many women worldwide. In the United States, 40,450 women succumbed to breast cancer in 2015, with an estimated 247,000 new cases being diagnosed in 2016. Approximately 15% of all breast cancer cases will be classified as triple negative breast cancer (TNBC), an aggressive form of breast cancer characterized by the lack of estrogen and progesterone receptors as well as normal expression of the human epidermal growth factor receptor 2 (HER2). These cellular properties thereby exclude patients diagnosed with TNBC from the benefits of current targeted agents. The aggressive nature of TNBC coupled with the lack of effective targeted therapies contribute to a greater patient mortality rate when compared to other breast cancer subtypes, underscoring a crucial need for novel development of actionable targets for this patient population.
subject
angiotensin-(1-7)
c-met
triple negative breast cancer
contributor
Deng, Guorui (author)
Tallant, Elisabeth A (committee chair)
Metheny-Barlow, Linda (committee member)
Miller, Lance D (committee member)
Singh, Ravi N (committee member)
date
2017-01-14T09:35:18Z (accessioned)
2018-01-13T09:30:09Z (available)
2016 (issued)
degree
Cancer Biology (discipline)
embargo
2018-01-13 (terms)
identifier
http://hdl.handle.net/10339/64173 (uri)
language
en (iso)
publisher
Wake Forest University
title
REGULATION OF C-MET RECEPTOR TYROSINE KINASE SIGNALING BY ANGIOTENSIN-(1-7) IN TRIPLE NEGATIVE BREAST CANCER
type
Dissertation

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