Item Details

title

REGULATION OF C-MET RECEPTOR TYROSINE KINASE SIGNALING BY ANGIOTENSIN-(1-7) IN TRIPLE NEGATIVE BREAST CANCER

author

Deng, Guorui

abstract

Breast cancer remains a devastating disease, negatively impacting the lives of many women worldwide. In the United States, 40,450 women succumbed to breast cancer in 2015, with an estimated 247,000 new cases being diagnosed in 2016. Approximately 15% of all breast cancer cases will be classified as triple negative breast cancer (TNBC), an aggressive form of breast cancer characterized by the lack of estrogen and progesterone receptors as well as normal expression of the human epidermal growth factor receptor 2 (HER2). These cellular properties thereby exclude patients diagnosed with TNBC from the benefits of current targeted agents. The aggressive nature of TNBC coupled with the lack of effective targeted therapies contribute to a greater patient mortality rate when compared to other breast cancer subtypes, underscoring a crucial need for novel development of actionable targets for this patient population.

subject

angiotensin-(1-7)

c-met

triple negative breast cancer

contributor

Tallant, Elisabeth A (committee chair)

Metheny-Barlow, Linda (committee member)

Miller, Lance D (committee member)

Singh, Ravi N (committee member)

date

2017-01-14T09:35:18Z (accessioned)

2018-01-13T09:30:09Z (available)

2016 (issued)

degree

Cancer Biology (discipline)

embargo

2018-01-13 (terms)

identifier

http://hdl.handle.net/10339/64173 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation