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PARTIAL SPINAL NERVE LIGATION ALTERS ANATOMICAL COMPONENTS OF OXYTOCIN SIGNALING AND THE LEVEL OF TONIC OXYTOCIN-MEDIATED INHIBITION OF NOCICEPTION

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abstract
Chronic pain affects more than 25 million people in the United States of America, with neuropathic pain contributing to pain in 6-8% of this population. Chronic pain occurs after surgical interventions in approximately 10-40% of patients, but most patients recover without developing persistent pain. Why some patients recover and others do not may be due to differences in activity of endogenous pain inhibition. Oxytocin is a peptide that has been characterized for its analgesic properties and recent studies suggest that oxytocin may contribute to endogenous inhibitory tone in chronic pain. We investigated mechanisms of oxytocin signaling that may be altered by partial spinal nerve ligation (pSNL) injury and contribute to the apparent recovery of pain after pSNL injury in rats.
subject
contributor
Severino, Amie Leigh Milliken (author)
Eisenach, James C (committee chair)
Coghill, Robert C (committee member)
Figueroa, Jorge P (committee member)
Martin, Thomas J (committee member)
Weiner, Jeffrey L (committee member)
date
2017-01-14T09:35:32Z (accessioned)
2016 (issued)
degree
Neuroscience (discipline)
2021-12-21 (liftdate)
embargo
2021-12-21 (terms)
identifier
http://hdl.handle.net/10339/64197 (uri)
language
en (iso)
publisher
Wake Forest University
title
PARTIAL SPINAL NERVE LIGATION ALTERS ANATOMICAL COMPONENTS OF OXYTOCIN SIGNALING AND THE LEVEL OF TONIC OXYTOCIN-MEDIATED INHIBITION OF NOCICEPTION
type
Dissertation

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