Item Details

abstract

The mechanisms of how organisms maintain metabolic homeostasis in light of significant environmental variation in food availability are not completely understood. In Drosophila, the mobilization of energy is primarily controlled by the endocrine factor Adipokinetic Hormone (AKH). AKH function is critical for proper energy allocation under ad libitum conditions, and is particularly important for the physiological and behavioral response to metabolic stress. Animals lacking AKH display multiple stress phenotypes including increased lifespan under starvation and the absence of starvation-induced locomotion. Research has primarily focused on understanding the downstream targets of AKH action, however, little work has explored AKH cell physiology and the mechanisms that govern AKH release.

subject

AKH

Drosophila

Metabolism

Starvation

contributor

Braco, Jason Thomas (author)

Johnson, Erik C (committee chair)

Marrs, Glen S (committee member)

Silver, Wayne L (committee member)

Zeyl, Clifford W (committee member)

date

2017-06-15T08:35:27Z (accessioned)

2021-12-30T09:30:14Z (available)

2017 (issued)

degree

Biology (discipline)

embargo

2021-12-30 (terms)

identifier

http://hdl.handle.net/10339/82158 (uri)

language

en (iso)

publisher

Wake Forest University

title

FUNCTIONAL DISSECTION OF ADIPOKINETIC HORMONE PRODUCING CELLS

type

Dissertation