Home WakeSpace Scholarship › Electronic Theses and Dissertations

FUNCTIONAL DISSECTION OF ADIPOKINETIC HORMONE PRODUCING CELLS

Electronic Theses and Dissertations

Item Files

Item Details

abstract
The mechanisms of how organisms maintain metabolic homeostasis in light of significant environmental variation in food availability are not completely understood. In Drosophila, the mobilization of energy is primarily controlled by the endocrine factor Adipokinetic Hormone (AKH). AKH function is critical for proper energy allocation under ad libitum conditions, and is particularly important for the physiological and behavioral response to metabolic stress. Animals lacking AKH display multiple stress phenotypes including increased lifespan under starvation and the absence of starvation-induced locomotion. Research has primarily focused on understanding the downstream targets of AKH action, however, little work has explored AKH cell physiology and the mechanisms that govern AKH release.
subject
AKH
Drosophila
Metabolism
Starvation
contributor
Braco, Jason Thomas (author)
Johnson, Erik C (committee chair)
Marrs, Glen S (committee member)
Silver, Wayne L (committee member)
Zeyl, Clifford W (committee member)
date
2017-06-15T08:35:27Z (accessioned)
2017 (issued)
degree
Biology (discipline)
2021-12-30 (liftdate)
embargo
2021-12-30 (terms)
identifier
http://hdl.handle.net/10339/82158 (uri)
language
en (iso)
publisher
Wake Forest University
title
FUNCTIONAL DISSECTION OF ADIPOKINETIC HORMONE PRODUCING CELLS
type
Dissertation

Usage Statistics