QUANTIFYING RADIATION INDUCED CORTICAL BONE LOSS USING COMPUTED TOMOGRAPHY (CT) IMAGING
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- abstract
- Bone fracture is a major complication of radiation therapy (RT). The etiology of RT-induced fractures is unclear, but likely involves bone damage and deterioration. Unfortunately, there remains a paucity of quantitative data on structural bone changes after exposure to RT. The primary goal of this project is to quantify RT-related structural bone changes in cancer patients using computed tomography (CT) scans obtained in the course of treatment. Our hypothesis is that exposure to radiation produces early structural changes in the cortical and trabecular bone compartments.
- subject
- Bone
- Computed Tomography
- Radiation
- Toxicity
- contributor
- Munley, Michael T (committee chair)
- Willey, Jeffery S (committee member)
- Blackstock, A. William (committee member)
- Weaver, Ashley A (committee member)
- Bourland, J.Daniel (committee member)
- date
- 2017-06-15T08:35:29Z (accessioned)
- 2019-06-14T08:30:12Z (available)
- 2017 (issued)
- degree
- Biomedical Engineering (discipline)
- embargo
- 2019-06-14 (terms)
- identifier
- http://hdl.handle.net/10339/82159 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- QUANTIFYING RADIATION INDUCED CORTICAL BONE LOSS USING COMPUTED TOMOGRAPHY (CT) IMAGING
- type
- Dissertation