Item Details

abstract

Cardiometabolic syndrome (CMS) is a clustering of interrelated risk factors (central obesity, hyperglycemia, hypertension, insulin resistance, and dyslipoproteinemia) that promotes the development of atherosclerotic vascular disease and type 2 diabetes. It was recognized as a disease entity by the American Society of Endocrinology, National Cholesterol Education Program (NCEP), and World Health Organization in 2003 (Castro, El-Atat, McFarlane, Aneja, & Sowers, 2003). Previous genetic studies with monozygotic and dizygotic twin pairs suggested a strongly heritable pattern for CMS risk factors, i.e. it is estimated that circulating lipid heritability ranges from 0.58 to 0.66 (h2HDL=0.61, h2LDL=0.59, h2TC=0.58, h2TG=0.66) (Knoblauch et al., 1997). However, the exact genetic mechanism of the disease is poorly understood.

subject

Cardiometabolic syndrome

Genetics

GWAS

Mexican Americans

contributor

Gao, Chuan (author)

Allred, Nicholette D. (committee chair)

Langefeld, Carl D. (committee member)

Bowden, Donald W. (committee member)

Parks, John S. (committee member)

Liu, Yongmei (committee member)

date

2017-06-15T08:35:29Z (accessioned)

2019-06-14T08:30:13Z (available)

2017 (issued)

degree

Molecular Genetics & Genomics (discipline)

embargo

2019-06-14 (terms)

identifier

http://hdl.handle.net/10339/82160 (uri)

language

en (iso)

publisher

Wake Forest University

title

INVESTIGATION OF THE GENETIC ARCHITECTURE OF CARDIOMETABOLIC DISEASE

type

Dissertation