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INVESTIGATION OF THE GENETIC ARCHITECTURE OF CARDIOMETABOLIC DISEASE

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abstract
Cardiometabolic syndrome (CMS) is a clustering of interrelated risk factors (central obesity, hyperglycemia, hypertension, insulin resistance, and dyslipoproteinemia) that promotes the development of atherosclerotic vascular disease and type 2 diabetes. It was recognized as a disease entity by the American Society of Endocrinology, National Cholesterol Education Program (NCEP), and World Health Organization in 2003 (Castro, El-Atat, McFarlane, Aneja, & Sowers, 2003). Previous genetic studies with monozygotic and dizygotic twin pairs suggested a strongly heritable pattern for CMS risk factors, i.e. it is estimated that circulating lipid heritability ranges from 0.58 to 0.66 (h2HDL=0.61, h2LDL=0.59, h2TC=0.58, h2TG=0.66) (Knoblauch et al., 1997). However, the exact genetic mechanism of the disease is poorly understood.
subject
Cardiometabolic syndrome
Genetics
GWAS
Mexican Americans
contributor
Gao, Chuan (author)
Allred, Nicholette D. (committee chair)
Langefeld, Carl D. (committee member)
Bowden, Donald W. (committee member)
Parks, John S. (committee member)
Liu, Yongmei (committee member)
date
2017-06-15T08:35:29Z (accessioned)
2019-06-14T08:30:13Z (available)
2017 (issued)
degree
Molecular Genetics & Genomics (discipline)
embargo
2019-06-14 (terms)
identifier
http://hdl.handle.net/10339/82160 (uri)
language
en (iso)
publisher
Wake Forest University
title
INVESTIGATION OF THE GENETIC ARCHITECTURE OF CARDIOMETABOLIC DISEASE
type
Dissertation

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