INVESTIGATION OF THE GENETIC ARCHITECTURE OF CARDIOMETABOLIC DISEASE
Electronic Theses and Dissertations
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Item Details
- abstract
- Cardiometabolic syndrome (CMS) is a clustering of interrelated risk factors (central obesity, hyperglycemia, hypertension, insulin resistance, and dyslipoproteinemia) that promotes the development of atherosclerotic vascular disease and type 2 diabetes. It was recognized as a disease entity by the American Society of Endocrinology, National Cholesterol Education Program (NCEP), and World Health Organization in 2003 (Castro, El-Atat, McFarlane, Aneja, & Sowers, 2003). Previous genetic studies with monozygotic and dizygotic twin pairs suggested a strongly heritable pattern for CMS risk factors, i.e. it is estimated that circulating lipid heritability ranges from 0.58 to 0.66 (h2HDL=0.61, h2LDL=0.59, h2TC=0.58, h2TG=0.66) (Knoblauch et al., 1997). However, the exact genetic mechanism of the disease is poorly understood.
- subject
- Cardiometabolic syndrome
- Genetics
- GWAS
- Mexican Americans
- contributor
- Allred, Nicholette D. (committee chair)
- Langefeld, Carl D. (committee member)
- Bowden, Donald W. (committee member)
- Parks, John S. (committee member)
- Liu, Yongmei (committee member)
- date
- 2017-06-15T08:35:29Z (accessioned)
- 2019-06-14T08:30:13Z (available)
- 2017 (issued)
- degree
- Molecular Genetics & Genomics (discipline)
- embargo
- 2019-06-14 (terms)
- identifier
- http://hdl.handle.net/10339/82160 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- INVESTIGATION OF THE GENETIC ARCHITECTURE OF CARDIOMETABOLIC DISEASE
- type
- Dissertation