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SILVER NANOPARTICLES ARE EFFECTIVE FOR THE TREATMENT OF CLAUDIN LOW BREAST CANCER AND OTHER MESENCHYMAL CANCERS WITH HIGH ZEB1 EXPRESSION

Electronic Theses and Dissertations

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abstract
A woman’s lifetime risk of being diagnosed with breast cancer is approximately 1 in 8, and it is estimated that over 40,000 women will die from BC in 2017. With advances in molecular profiling, breast cancer has been divided into 5 molecular subtypes (luminal A, luminal B, HER-2 overexpressing, basal-like, and claudin-low) that have distinct genetic aberrations, morphological features, prognoses, and therapeutic responses. Therefore, breast cancer should be treated with subtype specific therapies as these may provide the greatest therapeutic benefit.
subject
breast cancer
nanomaterials
novel therapeutics
reactive oxygen species
silver
contributor
Swanner, Jessica Lynn (author)
Singh, Ravi N (committee chair)
Kridel, Steven J (committee member)
Kucera, Gregory L (committee member)
Metheny-Barlow, Linda J (committee member)
date
2017-06-15T08:35:59Z (accessioned)
2018-06-14T08:30:10Z (available)
2017 (issued)
degree
Cancer Biology (discipline)
embargo
2018-06-14 (terms)
identifier
http://hdl.handle.net/10339/82205 (uri)
language
en (iso)
publisher
Wake Forest University
title
SILVER NANOPARTICLES ARE EFFECTIVE FOR THE TREATMENT OF CLAUDIN LOW BREAST CANCER AND OTHER MESENCHYMAL CANCERS WITH HIGH ZEB1 EXPRESSION
type
Dissertation

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