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NANOPARTICLE BASED MULTI-MODAL THERAPIES AGAINST TRIPLE-NEGATIVE BREAST CANCER

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abstract
Triple-negative breast cancer (TNBC) is a highly metastatic and lethal form of breast cancer that lacks surface markers commonly targeted by hormone or immunotherapies. Silver nanoparticles (AgNPs) have exhibited a selective toxicity against TNBC cell lines at concentrations that are not lethal to non-tumorigenic cells, which makes them a candidate for the development of a multimodal cancer therapy that uses a selectively cytotoxic particle that sensitizes cancerous cells to ionizing radiation and can act as a photothermal therapy heat transducer. Using a 90 nm triangular silver nanoparticle plate (AgNPP) allows for the nanoparticle to have a plasmon resonance that is in the near-infrared (NIR) spectrum. We hypothesize that the effectiveness of an AgNP therapy against TNBC can be enhanced by using photothermal therapy (PTT) and ionizing radiation in combination with the AgNP. We show that AgNPPs can be used to develop a selectively cytotoxic multimodal therapy against TNBC cells line without affecting non-tumorigenic cells. Combining the cytotoxicity of the nanoparticles, PTT, and ionizing radiation can reduce the viability of TNBC beyond each individual treatment. We also show that super paramagnetic iron oxide nanoparticles may also be suitable to serve as a base for the development of a multimodal cancer therapy.
subject
Ionizing Radiation
Photothermal Therapy
Silver Nanoparticle Plates
Super Paramagnetic Iron Oxide
Triple Negative Breast Cancer
contributor
Sears, James Jerod (author)
Singh, Ravi N (committee chair)
Singh, Ravi N (committee member)
Latham-Sadler, Brenda (committee member)
Whitlow, Christopher T (committee member)
date
2017-06-15T08:36:05Z (accessioned)
2018-06-14T08:30:12Z (available)
2017 (issued)
degree
Biomedical Science – MS (discipline)
embargo
2018-06-14 (terms)
identifier
http://hdl.handle.net/10339/82220 (uri)
language
en (iso)
publisher
Wake Forest University
title
NANOPARTICLE BASED MULTI-MODAL THERAPIES AGAINST TRIPLE-NEGATIVE BREAST CANCER
type
Thesis

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