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Neuromuscular Ultrasound as a Biomarker of Disease Progression in ALS

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abstract
This study focused on determining whether neuromuscular ultrasound may be a viable option for monitoring ALS progression. Other biomarkers currently available have limiting factors such as subjectivity and invasiveness. 12 participants took part in our study and we measured the thickness of four muscle groups including the biceps brachii, tibialis anterior, geniohyoid, and hemi-diaphragm at both inhalation and exhalation. We measured three times over six months and found significant changes. All muscle groups showed an expected decrease in thickness. When the percentage decline of muscle thickness was correlated to a decline in ALS Functional Rating Scale score (ALSFRS) and Forced Vital Capacity (FVC), the biceps, tibialis anterior, and diaphragm at both inhalation and exhalation showed significant correlations to FVC. The biceps muscle thickness percent decrease also correlated significantly to ALSFRS decline. The ultrasound method provided a strong and accurate measurement for analyzing muscle thickness decrease in ALS patients in this study. The significant findings of this study and success of the experimental method suggest that there is a basis for further such clinical trials on larger groups of ALS patients in the future.
subject
ALS
Muscle
Neuromuscular
Ultrasound
contributor
Williams, Delaney Elizabeth (author)
Cartwright, Michael S (committee chair)
McCormick, James G (committee member)
Caress, James B (committee member)
date
2017-06-15T08:36:07Z (accessioned)
2017-06-15T08:36:07Z (available)
2017 (issued)
degree
Biomedical Science – MS (discipline)
identifier
http://hdl.handle.net/10339/82228 (uri)
language
en (iso)
publisher
Wake Forest University
title
Neuromuscular Ultrasound as a Biomarker of Disease Progression in ALS
type
Thesis

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